Obesity is the most common illness, resulting in development of various somatic or endocrinal pathologies.
It happens that overweight patients develop hormone dependent endocrine diseases, such as hypothyroidism.
The main cause of hypothyroidism is autoimmune thyroiditis (inflammation of thyroid gland). However, early and timely hormonal therapy helps in eliminating of this disease’s symptoms. In addition, weight loss can improve the hormonal profile.
To reduce the body mass, doctors recommend patients with hypothyroidism to use the prescription appetite suppressants. Phentermine is the most prescribed appetite suppressant all over the world. In South Asia and Asia-Pacific regions, Phentermine drug is sold under the brand name Duromine.
Duromine weight loss drug is prescribed for a short-term anti-obesity therapy, lasting for 12 weeks. Duromine (Phentermine) must be combined with diet and physiotherapy. Thus, an obese person can reduce his body weight down to 10-15% of starting weight.
If intensive anti-obesity therapy helps in weight loss, but does not restore the endocrine system functions, hormonal therapy can be prescribed to obese people.
There is reliably known data that after the beginning of hormonal therapy, some obese people have lost weight.
However, these people’s weight loss occurred due to the loss of excess fluid, but not the adipose tissue. Thus, the inhibition of synthesis of thyroid stimulating hormone (TSH) in obese patients with hypothyroidism does not change the body weight.
Safety and efficiency trials on usage of thyroid hormones and weight loss drugs (in particular Duromine) are still going on. So far, scientists found out that a concomitant use of the thyroid hormones (iodothyronine polypeptide and calcitonin hormones) and Duromine leads to severe form of thyrotoxicosis. In some cases, a joint application of Duromine and thyroid hormones leads to a thyrotoxic periodic paralysis.
However, when patients were using Duromine along with analogues of thyroid hormones (3.5-diiodo-L-thyronine), a weight loss without any undesirable effects was recorded. Thus, the anti-obesity therapy in obese people with hypothyroidism must involve: hypocaloric diet, daily moderate physical exertion, weight loss drug Duromine and Levothyroxine in supportive dose.